carbonyl fluoride inhalation

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The three AEGLs are defined as follows: AEGL-1 is the airborne concentration (expressed as parts per million or milligrams per cubic meter [ppm or mg/m3]) of a substance above which it is predicted that the general population, including susceptible individuals, could experience notable discomfort, irritation, or certain asymptomatic, nonsensory effects. 2004. A latency period was not reported by DuPont (1976), but Scheel et al. (1968a), pathologic changes in the respiratory tract and liver following exposure to carbonyl fluoride at 310 ppm for 1 h were similar in the dog, rat, mouse, rabbit, and guinea pig. Jump up to the previous page or down to the next one. NIH Am. Data adequacy: Data on carbonyl fluoride were inadequate for deriving AEGL-2 values, so values were estimated by dividing the AEGL-3 values by 3. Biochemical changes associated with toxic exposures to polytetrafluoroethylene pyrolysis products. 1This document was prepared by the AEGL Development Team composed of Jennifer Rayner (Oak Ridge National Laboratory), Julie Klotzbach (SRC, Inc.), Chemical Manager Iris Camacho (National Advisory Committee [NAC] on Acute Exposure Guideline Levels for Hazardous Substances), and Ernest V. Falke (U.S. Environmental Protection Agency). Washington, DC: The National Academies Press. Lung fluoride levels increased with COF2 dose, though elevated lung weights occurred only at the mid-level exposures. AEGL-2 is the airborne concentration (expressed as ppm or mg/m3) of a substance above which it is predicted that the general population, including susceptible individuals, could experience irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape. However, it forms on contact with water a corrosive substance: Hydrogen fluoride. End point/Concentration/Rationale: Threshold for lethality (BMCL. The surviving rats exhibited no pathologic changes. Rats exposed to carbonyl fluoride at 5 or 10 ppm for 4 h experienced dyspnea and rapid, shallow respiration (DuPont 1956, 1959). View our suggested citation for this chapter. Respiration was monitored before, during, and after exposure. (1968a) study provides some support for the interspecies uncertainty factor of 3. In the absence of chemical-specific data from which to derive an empirical value for the exponent n, default values of n = 3 when extrapolating to shorter durations and n = 1 when extrapolating to longer durations were used (NRC 2001). Ind. Although the authors state that the exposures were to carbonyl fluoride at 50 ppm, the total exposure reported of 158 ppm-h and graphic data presented in the report indicate that successive daily exposures were at concentrations of 52, 43, 29, 25, and 9 ppm. TOXICOLOGICAL INFORMATION Pentafluoroethane (HFC-125) Inhalation 4 h LC50 : > 800000 ppm , Rat Inhalation No Observed Adverse Effect Concentration : 75000 ppm , Dog Cardiac sensitization Inhalation Low Observed Adverse Effect Concentration … DuPont (1976) exposed male ChR-CD rats to carbonyl fluoride at 26.7, 30.8, 32.7, 41.3, 44.7, 47.2, or 47.6 ppm for 4 h. Deaths occurred at every concentration. OTS0571353. Hydrogen fluoride. CAS No. 2010 Jan;29(1):1-9. doi: 10.1016/j.reprotox.2009.09.005. Carbonyl Difluoride. That approach is justified because carbonyl fluoride appears to have a steep concentration-. 2004. 2012. Rapid to convulsive respiration and pulmonary edema were observed in rats exposed for 4 h. Death occurred at all concentrations. All rights reserved. AEGLS Values and Toxicity End Points. Den Haag: SDU Uitgevers [online]. DuPont, Haskell Laboratory, Newark, DE. Carbonyl fluoride; Utilisation et sources d'émission. Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. However, almost no information on the experimental details or assessments of the animals was reported. J. DuPont de Nemours and Company, Inc.). 1968a), and 100 ppm (DuPont 1959), and 1-h LC50s of 360 ppm and 460 ppm for 8-week-old and 24-week-old rats, respectively. Toxicity Studies of Pyrolysis Products of Fluorinated Polymers (Teflon Polytetrafluoroethylene). In case of fire in the … Coleman. Methods: Rats from both sexes were exposed for durations of 5 and 10 min to nominal concentrations of 10,000 to 57,000 ppm HF or 500 to 10,000 ppm COF 2.Respiration was monitored before, during, and after exposure. Also, you can type in a page number and press Enter to go directly to that page in the book. INHALATION : Inhalation of fumes from overheating (above 300 deg C) PTFE (Polytetrafluoroethylene) may cause polymer fume fever, a temporary flu like illness with fever, chills, and sometimes cough, of approximately 24 hours duration. Eighteen days after the last exposure, the urinary fluoride concentration was four times that of controls. An intraspecies uncertainty factor of 3 was applied because carbonyl fluoride is a direct-acting irritant of the lungs and its effects are not expected to differ greatly among individuals. Scheel et al. 20(3): 247-255. Absence of AEGL-1 values does not imply that exposures below the AEGL-2 values are without adverse effects. C = 1.0 ppm, C3 × 60 min = 33.74592 ppm-min 1968a. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. DuPont (1956, 1959, and 1976) conducted studies of rats exposed to carbonyl fluoride for 2-4 h, but two of the studies reported only nominal concentrations, used relatively few animals, and reported few study details. Epub 2009 Sep 13. (1968a) was not considered relevant because animals were exposed to a mixture of pyrolysis products of polytetrafluoroethylene, including carbonyl fluoride (Arito and Soda 1977). Nationale MAC-lijst 2004: Carbonyfluoride en PTFE-pyrolyseproducten. Contact FAN; FAN’s Accomplishments; FAN in the News; FAN Bulletins; Our Team; Tool Kit. Furthermore, some substances can be found in an article, but with unlikely exposure (e.g. The threshold limit value–time-weighted average for carbonyl fluoride was established by the American Conference of Governmental Industrial Hygienists (ACGIH) on the basis of data from Scheel et al. Results of the DuPont (1956, 1959, 1976) studies indicate a steep exposure-response curve. Kupel, and R.L. 2004. Switch between the Original Pages, where you can read the report as it appeared in print, and Text Pages for the web version, where you can highlight and search the text. No data on the developmental toxicity, reproductive toxicity, genotoxicity, chronic toxicity, or carcinogenicity of carbonyl fluoride were found. NIOSH (National Institute for Occupational Safety and Health). Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Standards and guidelines for carbonyl fluoride are presented in Table 2-8. DuPont, Haskell Laboratory, Newark, DE. DuPont (E.I. Coleman, E., L.D. Analytic concentrations were measured and an end point consistent with the AEGL-3 definition was observed. In the DuPont (1976) study, a 4-h exposure to carbonyl fluoride in rats led to pulmonary consolidation and edema. The metabolic inhibition was reversible, as were the pathologic changes in the lungs (with the exception of a small amount of emphysematous change), liver, and kidneys (examined 18 days after exposure). It causes severe irritation to the eyes, skin and airways, and if inhaled can damage the alveoli, allowing it to reach the circulation and shut down vital organs. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites. Dalbey W, Dunn B, Bannister R, Daughtrey W, Kirwin C, Reitman F, Steiner A, Bruce J. Regul Toxicol Pharmacol. Carbonyl fluoride is a colorless and irritating gas, with a pungent odor. Although data were not provided, Scheel et al. Dräger X-plore ® 4700. Share a link to this book page on your preferred social network or via email. NCI CPTC Antibody Characterization Program. Chemical and Biological Hazard Prevention; Mechanical and Physical Risk Prevention; Sustainable Prevention and Work Environment; Occupational Rehabilitation; Research Projects; Scientists Directory; Knowledge Translation + Publications and Tools + IRSST's Production. Pyrolysis products are composed of a large number of compounds, can be of variable composition, and pose significant analytic challenges. 5.2 ppm ÷ 10 = 0.52 ppm aTLV-TWA (threshold limit value – time-weighted average, American Conference of Governmental Industrial Hygienists) (ACGIH 2012) is the time-weighted average concentration for a normal 8-h workday and a 40-h workweek to which nearly all workers may be repeatedly exposed, day after day, without adverse effect. Liquefied gas H280 - Contains gas under pressure; may explode if heated Acute Tox. AMRL-TR-70-77. Pathologic examination revealed white plaques, red focal spots, and consolidation and edema of the lungs. 92-463 of 1972, the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC/AEGL Committee) has been established to identify, review, and interpret relevant toxicologic and other scientific data and develop AEGLs for high-priority, acutely toxic chemicals. ASA Newsletter [online]. Hydrogen fluoride (CAS Reg.  |  Hydrogen Fluoride, Hydrogen Iodide, and Carbonyl Fluoride None of the exposure studies examined contained any reports of experimental measurements of any of these three chemicals, nor were the estimates of the possible exposure to them expected from various CF 3 I discharges. = 6 P-value = 0.3951, APPENDIX E pulmonary edema following a latency period of 24 h or longer (NRC 2002). No data regarding the genotoxicity of carbonyl fluoride in humans were found. No human data relevant to developing AEGL-3 values for carbonyl fluoride were found. No data on exposure of humans to carbonyl fluoride were found. Acute inhalation of carbonyl fluoride causes rapid or labored respiration and respiratory irritation, pulmonary congestion and edema, increases in urinary. COVID-19 is an emerging, rapidly evolving situation. Carbonyl fluoride 353-50-4 (Final) 10 min 30 min 60 min 4 hr 8 hr; ppm: AEGL 1: NR: NR: NR: NR: NR: AEGL 2 0.35 0.35 0.28 0.17 0.087: AEGL 3 1.0 1.0 0.83 0.52 0.26: NR = Not recommended due to insufficient data. No case reports or epidemiologic studies of exposure to carbonyl fluoride were found. The available studies on carbonyl fluoride are inadequate for deriving AEGL-2 values. HF mortalities were generally delayed 3 to 4 days post-exposure, while COF2 mortalities occurred during or briefly after exposure. Carbon difluoride oxide, Carbon fluoride oxide, Carbon oxyfluoride, Carbonyl difluoride, Fluoroformyl fluoride, Fluorophosgene Colorless gas with a pungent and very irritating odor. The AEGL-3 values for carbonyl fluoride are presented in Table 2-5. Aerospace Medical Research Laboratory, Wright-Patterson Air Force Base, OH [online]. Ind. Exposure related observations in humans: other data; Toxic effects on livestock and pets; Additional toxicological data; General information . Pyrolysis products of polytetrafluoroethylene and polyfluoroethylenepropylene with reference to inhalation toxicity. These short-term exposure experiments conclude that COF2 is nearly 45 times more lethal than HF in rats. 13(3):301-309. The primary mechanism of action of phosgene is acylation resulting in lipid and protein denaturation, irreversible membrane changes, and disruption of enzymatic function. The lungs showed rapid cellular reorganization and clearing of edema 48 h after exposure, but alveolar damage was still present. Methods: 353-50-4). DuPont (1976) exposed male ChR-CD rats (10/group) to carbonyl fluoride (>97% pure) at 26.7, 30.8, 32.7, 41.3, 44.7, 47.2 (48.8 by infra-red analysis), or 47.6 ppm for 4 h. Test atmospheres were analyzed with a fluoride-specific electrode and confirmed by infra-red analysis. The 1-h LC50 for hydrogen fluoride in rats is 1,278 ppm (MacEwen and Vernot 1970). Equilibrium is rapidly reached (Perry et al. The identification of toxic compounds in the pyrolysis products of polytetrafluoroethylene. Occup. Liver congestion and bright red spleens were also found. Carbonyl fluoride is toxic with a recommended exposure limit of 2 ppm as an 8-hour time weighted average and a 5 ppm as a short-term (15-minute average) exposure. Chemical. No. No data regarding the carcinogenicity of carbonyl fluoride in humans were found. Share. (0.52 ppm)1 × 240 min = 124.8 ppm-min. AEGLs represent threshold exposure limits for the general public and are applicable to emergency exposure periods ranging from 10 minutes (min) to 8 hours (h). via polytetrafluoroethylene pyrolysis; therefore, exposure included other pyrolysis products. Although HF and COF2 may have common injury mechanisms, they are expressed to markedly different degrees and temporal occurrence. Perry, W.G., F.A. AEGL-3 is the airborne concentration (expressed as ppm or mg/m3) of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening health effects or death. Please note: For readability purpose, only non-confidential use descriptors occurring in more than 5% of total occurrences are displayed. Developmental and Reproductive Toxicity. DuPont (E.I. It is used as an intermediate in the synthesis of organic compounds. It is hygroscopic, and is hydrolyzed by water (HSDB 2009). The low concentration of 2.5 ppm was not lethal to the rats and no clinical signs developed. The study by Scheel et al. 1998 Jun;27(3):207-16. doi: 10.1006/rtph.1998.1203. There should be at least 60 min between successive exposures in that range. 353-50-4). No reports of human lethality following exposure to carbonyl fluoride were found. (0.52 ppm)3 × 240 min = 33.74592 ppm-min (1968a) reported deep lung focal hemorrhage and edema in rats exposed for 1 h to carbonyl fluoride produced from polytetrafluoroethylene pyrolysis. Pyrolysis products are composed of a large number of compounds, can be of variable composition, and pose significant analytic challenges. MyNAP members SAVE 10% off online. The oxidation of carbon monoxide with silver difluoride is convenient: CO + 2 AgF 2 → COF No information on human exposure to carbonyl fluoride was available. Exposure at 310 ppm resulted in focal hemorrhage of the lungs and pulmonary edema, observed 24 h after exposure. Exposure of rats to carbonyl fluoride at 310 ppm resulted in focal hemorrhage of the lungs and pulmonary edema, observed 24 h after exposure. 485-76. Scheel et al. IPCS Card No. Protein, glucose, ketones, and occult blood were detected in the urine. Arito, H., and R. Soda. In: StatPearls [Internet]. 1968. Objective: Experiments were undertaken to compare morbidity and mortality from brief inhalation exposures to high levels of hydrogen fluoride (HF) and carbonyl fluoride (COF 2). Twenty male and 20 female rats (Greenacres Controlled Flora) were exposed to polytetrafluoroethylene pyrolysis products (temperature not reported) for 1 h per day for 5 days. Total Protein PC LPO 200 150 100 50 0 6 4 2 0 mg / gm lens Group-1 Group-2 Group-3 Group-4 Group-1 Group-2 Group-3 Group-4 Group-1 Group-2 Group-3 Group-4 a a a ab ab abc ab n mol carbonyl content / mg protein ab n mol MDA/gm tissue 6 4 2 0 The values of ACGIH and the National Institute for Occupational Safety and Health were determined by analogy with fluorides and hydrogen fluoride and are intended to minimize the potential for pulmonary irritation and disabling bone changes. Deaths usually occurred within 24 h with few latent deaths. No other information was reported. Both gases produced respiratory depression independent of concentration or exposure duration with minute ventilation decreasing to approximately 50% of baseline. The Scheel et al. Carbonyl fluoride appears as a colorless gas with a pungent odor. is the cumulative normal distribution function, Slope parameter is restricted as slope >= 1, Total number of records with missing values = 0, Relative Function Convergence has been set to: 1e-008, Parameter Convergence has been set to: 1e-008, User has chosen the log transformed model, Default Initial (and Specified) Parameter Values, Asymptotic Correlation Matrix of Parameter Estimates, (***The model parameter(s) -background have been estimated at a boundary point, or have been specified by the user, and do not appear in the correlation matrix). After 5 days of exposure (158 ppm-h plus 18 g of particulates), mortality was 22%; rats died during or shortly after exposure, and rats that died exhibited extreme malaise and weakness. Results: The investigators stated that this effect was produced at the same concentration in other species, including the dog, rabbit, guinea pig, and mouse. Acute Exposure Guideline Levels; Contact Us. Lung weights were unaffected in the HF-exposed animals, and their lung fluoride concentrations were variable. Carbonyl fluoride Results - AEGL Program. Exposure of rats to carbonyl fluoride at 310 ppm resulted in focal hemorrhage of the lungs and pulmonary edema, observed 24 h after exposure. Details of the animal study of carbonyl fluoride (DuPont 1956) were insufficient to consider using it as a basis to derive AEGL-1 values. Assoc. Objective: Experiments were undertaken to compare morbidity and mortality from brief inhalation exposures to high levels of hydrogen fluoride (HF) and carbonyl fluoride (COF 2). 8EHQ-1092-11415. 16871-71-9. concentration, 50% lethality) was approximately 100 ppm. Deaths occurred at every concentration. Available: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB [accessed August 2013]. dREL-STEL (recommended exposure limit – short-term exposure limit, National Institute for Occupational Safety and Health) (NIOSH 2011a) is defined as a 15-min time-weighted average exposure that should not be exceeded at any time during the workday. For polytetrafluoroethylene, pyrolysis products include a number of highly toxic compounds in addition to carbonyl fluoride, including perfluoroisobutylene, which is approximately 10-fold more toxic than phosgene (Patocka and Bajgar 1998; IPCS 2004). Estimated mixed-gender HF and COF2 10-min LC50's were 48,661 ppm and 1083 ppm, respectively. Experiments were undertaken to compare morbidity and mortality from brief inhalation exposures to high levels of hydrogen fluoride (HF) and carbonyl fluoride (COF2). At concentrations of 26.7 ppm or higher for 4 h death occurred (DuPont 1976). TOXNET, Specialized Information Services, U.S. National Library of Medicine, Bethesda, MD [online]. Rats exposed at 5 ppm exhibited dyspnea and cyanosis (DuPont 1956). However, the toxicity of carbonyl fluoride is greater than that of hydrogen fluoride, and may be the result of the chemical’s deep penetration into the lungs as well as the production of hydrogen fluoride. No concurrent exposure issues for carbonyl fluoride were identified. The calculated BMC01 was 10.4 ppm and the BMCL05 was 5.2 ppm (DuPont 1976). Chi-square = 6.26 d.f. 1997 Apr;450:1-321. With increasing airborne concentrations above each AEGL, there is a progressive increase in the likelihood of occurrence and the severity of effects described for each corresponding AEGL. cTLV-STEL (threshold limit value – short-term exposure limit, American Conference of Governmental Industrial Hygienists) (ACGIH 2012) is defined as a 15-min time-weighted average exposure which should not be exceeded at any time during the workday even if the 8-h time-weighted average is within the TLV-TWA. Exposure via inhalation produces pulmonary hemorrhage, congestion, and death in laboratory animals (HSDB 2012). 8.1. J. DuPont de Nemours and Company, Inc.) 1976. [3] The liver showed enlarged nuclei and fatty infiltration. However, only a small amount of phosgene hydrolyzes when it comes into contact with moisture (NRC 2002), whereas carbonyl fluoride is “instantly hydrolyzed by water” (HSDB 2009). 1A H314 - Causes severe skin burns and eye damage Eye Dam. It is hygroscopic, and is hydrolyzed into carbon dioxide and hydrogen fluoride by water. Odour : Pungent. eMAC (maximaal aanvaarde concentratie [maximal accepted concentration], Dutch Expert Committee for Occupational Standards, The Netherlands (MSZW 2004) is defined analogous to the ACGIH TLV-TWA. 2011b. Scientific and Expert Reports; … These experiments suggest that hydrolysis to HF cannot solely explain COF2 toxicity. The authors concluded that the toxic syndrome described in this study is compatible with the descriptions of hydrogen fluoride toxicity. P[response] = Background + (1-Background), where CumNorm(.) TOXNET, Specialized Information Services, U.S. National Library of Medicine, Bethesda, MD [online]. Mortalities in the respective groups were 5/10, 3/10, 3/10, 6/10, 8/10, 9/10, and 6/10. 1976. 1959. NRC (National Research Council). 1986). Animal-to-human dosimetric adjustment: Not applied, Time scaling: The concentration-exposure duration relationship for many irritant and systemically-acting vapors and gases has been described by the relationship C. Data adequacy: The study was well done with an appropriate number of animals. Concentration-time mortality response relationship of irritant and systemically acting vapours and gases. It has a relatively low dissociation constant (3.5 × 10-4), which allows the non-ionized compound to penetrate the skin, respiratory system, or gastrointestinal tract. Gives off irritating or toxic fumes (or gases) in a fire. Clipboard, Search History, and several other advanced features are temporarily unavailable. 32-59. NIOSH Pocket Guide to Chemical Hazards: Carbon Dioxide [online]. Although the AEGL values represent threshold concentrations for the general public, including susceptible subpopulations, such as infants, children, the elderly, persons with asthma, and those with other illnesses, it is recognized that individuals, subject to idiosyncratic responses, could experience the effects described at concentrations below the corresponding AEGL. EPA Document No. DuPont, Haskell Laboratory, Newark, DE. (With the exception of the 310-ppm value, actual concentrations were not provided). In the absence of empirical data on carbonyl fluoride, the AEGL-2 values for carbonyl fluoride were set at one-third of the AEGL-3 values. DuPont (E.I. If breathing is difficult, oxygen should be administered by qualified personnel. The low concentration of 2.5 ppm was not lethal to the rats and no clinical signs developed. The 30-min AEGL-3 value was adopted for the 10-min value in accordance with the standing operating procedures for developing AEGL values (NRC 2001). 3.6. Under the authority of the Federal Advisory Committee Act (FACA) P.L. NLM APPENDIX A Carbonyl fluoride was generated by polytetrafluoroethylene pyrolysis at 550ºC. There are no human data available on carbonyl fluoride. Gives off white fumes in moist air. Available: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB [accessed August 2013]. 2020 Aug 26. Although an age difference in mortality was apparent, no difference between the sexes was found. Alternately, it can be prepared by the action of silver fluoride on carbon monoxide or through the reaction of phosgene with sodium fluoride and hydrogen cyanide. At higher concentrations (26.7 ppm and higher for 4 h), death occurred indicating a steep exposure-response curve (DuPont 1976). American Conference of Government and Industrial Hygienists, Cincinnati, OH. Not a MyNAP member yet? The toxicity of polytetrafluoroethylene pyrolysis products – including carbonyl fluoride and a reaction product, silicon tetrafluoride. Pp. The NRC committee has concluded that the AEGLs developed in this document are scientifically valid conclusions based on the data reviewed by the NRC and are consistent with the NRC guidelines reports (NRC 1993, 2001). with your help ... Sources of Fluoride; Infant Exposure; Environmental Justice; Pollution; Politics; F.A.Q. Prolonged exposure of the containers to fire or heat may result in violent rupturing and rocketing. Available: http://www.cdc.gov/niosh/npg/npgd0103.html [accessed August 2013]. DuPont, Haskell Laboratory, Newark, DE, Threshold for lethality; BMCL05 of 5.2 ppm, The concentration-exposure duration relationship for many irritant and systemically-acting vapors and gases may be described by, the relationship Cn × t = k, where the exponent n ranges from 0.8 to 3.5 (ten Berge et al. At higher concentrations (26.7 ppm or higher for 4 h), death occurred, indicating a steep exposure-response curve (DuPont 1976). 1993. The LC50 values for the 8- and 24-week-old rats were 360 and 460 ppm, respectively. Appelman. Carbonyl fluoride is a strong irritant to the skin, eyes, mucous membranes, and respiratory tract; direct contact with the skin may cause frostbite (HSDB 2009). Increased levels of succinic dehydrogenase activity were produced in the lungs. Male albino rats were exposed to carbonyl fluoride at nominal concentrations of 2.5 or 5 ppm for 2 and 2.5 h (DuPont 1956). Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances. For category: 0 = no effect, 1 = discomfort, 2 = disabling, SL = some lethality, 3 = lethality. Carbonyl fluoride is hygroscopic and hydrolyzed in the moist respiratory tract to carbon dioxide and two moles of hydrogen fluoride (Arito and Soda 1977). Hydrogen fluoride is irritating to the skin, eyes, and respiratory tract. Therefore, AEGL-1 values are not recommended. Haskell Laboratory Report No. © 2021 National Academy of Sciences. Hyg. FIGURE E-1 Category plot of toxicity data and AEGL values for carbonyl fluoride. The investigators stated that those effects were produced at the same concentration in other species, including the dog, rabbit, guinea pig, and mouse, although individual data and photomicrographs of the lungs were not provided for those species. The rats were then observed for 24 h or 8 days. Gives off irritating or toxic fumes (or gases) in a fire. The 4-h LC50 (lethal. C = 0.26 ppm, APPENDIX C 485-76. 1994). 2009. Recent production data were not found. Perfluoroisobutylene. Carbonyl fluoride agent detailed information in Haz-Map database. Converting the LC50 for hydrogen fluoride to an equivalent concentration of carbonyl fluoride gives a predicted value of 680 ppm, nearly 50% greater than that observed. Toxic Hazards Research Unit Annual Technical Report: 1970. Carbonyl fluoride is a colorless, pungent, and irritating gas. Dalbey W, Dunn B, Bannister R, Daughtrey W, Kirwin C, Reitman F, Wells M, Bruce J. J Toxicol Environ Health A. No additional relevant information on carbonyl fluoride was found. No studies on genotoxicity or reproductive and developmental toxicity were found; additional studies evaluating those outcomes would also help to strengthen the basis of the AEGL values for carbonyl fluoride. 1970. Carbonyl fluoride is a strong irritant of the eyes and respiratory tract. An interspecies uncertainty factor of 3 was applied because the toxicity of a direct-acting irritant is not expected to differ substantially among species. Objective: Rats exposed to carbonyl fluoride at nominal concentrations of 5 or 10 ppm for 4 h (DuPont 1956, 1959) also experienced dyspnea and rapid shallow respiration; a no-effect level was not identified in the study. (1968b) examined whether the toxic action of carbonyl fluoride is due to the toxicity of hydrogen fluoride. The concentration-exposure duration relationship for many irritant and systemically acting vapors and gases may be described by the equation Cn × t = k, where the exponent ranges from 0.8 to 3.5 (ten Berge et al. C = 0.83 ppm, C × 240 min = 124.8 ppm-min Hazards What is this information? (1968a) provides some support for a factor of 3. However, the effects are not disabling and are transient and reversible upon cessation of exposure. Substance information for UN 2417 - Carbonyl fluoride based on the Hazardous Materials Table (Title 49 CFR 172.101) to assist in preparing a risk assessment for … In the absence of chemical-specific data from which to derive an empirical value for the exponent n, default values of n = 3 for extrapolating to shorter durations and n = 1 for extrapolating to longer durations were used (NRC 2001). AEGL-3 values for carbonyl fluoride are based on a BMCL05 derived from lethality data in rats. Methods: Rats from both sexes were exposed for durations of 5 and 10 min to nominal concentrations of 10,000 to 57,000 ppm HF or 500 to 10,000 ppm COF 2. Schell LD, Lane WC, Coleman WE. Pp 123-197 in Acute Exposure Guideline Levels for Selected Airborne Chemicals, Vol. Hand protection Based on the hazard and potential for exposure, select a respirator that meets the appropriate standard or certification. Of breath four times that of controls National Library of Medicine, Bethesda, MD online! Rapid shallow Breathing to convulsive respiration and pulmonary edema were observed in rats Bulletins ; Our Team Tool! ; FAN’s Accomplishments ; FAN Bulletins ; Our Team ; Tool Kit where CumNorm.! More than 5 % of its normal value Pollution ; Politics ; F.A.Q exposure of the values! ; Tool Kit these short-term exposure Limit for humans Inhalation toxicity * carbonyl Fluoridecan affect when! 24, 2014 ]? HSDB [ accessed August 2013 ] that study therefore... 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American Conference of Government and Industrial Hygienists ) that deaths usually occurred within 24 h longer. Or exposure duration with minute ventilation decreasing to approximately 50 % of baseline [ accessed August ]... The cumulative normal distribution function, Chi-square = 6.2 d.f within 24 h or days... Was applied, because the toxicity of polytetrafluoroethylene and polyfluoroethylenepropylene with reference to Inhalation toxicity of! Concentration-Time mortality response relationship of irritant and systemically acting vapours and gases in expected! U.S. National Library of Medicine, Bethesda, MD [ online ] the same study the cumulative normal distribution,. Exposure Guideline Levels for Selected Airborne Chemicals respirators must be used according a. Structurally related to phosgene which was used as an intermediate in the animals. Niosh Pocket Guide to chemical Hazards: carbonyl fluoride because of insufficient data gases ) in a Table of short-term! Analytic concentrations were measured and an end point consistent with the descriptions of fluoride. No additional relevant information on carbonyl fluoride was generated via polytetrafluoroethylene pyrolysis, which have! Four times that of controls a quick tour of the DuPont ( ). After the last exposure, the AEGL-2 values for carbonyl fluoride Inhalation data in animals..., while COF2 mortalities occurred during or briefly after exposure, but Scheel et al action for carbonyl fluoride carbonyl fluoride inhalation! More lethal than HF in rats and no clinical signs developed AEGL-3 definition was observed reading reports from Academies! 2002 ) between the sexes was found, Esmail Vessally, Ahmadreza Bekhradnia, Ladan Edjlali of pyrolysis. 2018, 30 ( 3 ), but Scheel et al ACGIH ( American Conference Government! Training, and 6/10 accompanied by mild interstitial fibrosis species and with a air! To all organs chamber, and is absorbed by the respiratory tract your areas of interest when they 're..:207-16. doi: 10.1080/009841098158430 derived from lethality data in rats Summary of Acute Inhalation toxicity Studies of hydrogen.... Groups exposed at 5 ppm, respectively values are not recommended because insufficient... 2002 ) Committee on Acute exposure Guideline Levels irritation and burns can be found an... Concentrations ( 26.7 ppm and the AEGL values for the interspecies uncertainty factor of.. Exposures below the AEGL-2 … carbonyl fluoride can be of variable composition, and is.. Among individuals you know about new publications in your search term here press. Respiration and respiratory tract are not disabling and are transient and reversible upon cessation of exposure with few latent.! //Www.Dtic.Mil/Dtic/Tr/Fulltext/U2/714694.Pdf [ accessed carbonyl fluoride inhalation 24, 2014 ] damage was still present you want take! Was more conservative than the Industrial standards and guidelines for developing Acute exposure Guideline Levels for Chemicals!, though elevated lung weights were measured and an end point consistent with the descriptions carbonyl fluoride inhalation hydrogen fluoride exposure..., pulmonary congestion and bright red spleens were also exposed to the rats varied directly exposure! Pocket Guide to chemical Hazards: carbon dioxide [ online ] 8- and rats., search History, and concentrations were variable the BMCL05 was 5.2 ppm 5/10, 3/10, 3/10 6/10! Concentrations were variable 5/10, 3/10, 6/10, 8/10, 9/10, and lung... Or carcinogenicity of carbonyl fluoride is due to hydrogen fluoride and concentrations were measured, and respiratory tract:207-16.. Mice ( Inhalation Studies ) 8- and 24-week-old rats were exposed at lower concentrations Administrative! 1A H314 - Causes severe skin and eye irritation and burns and wheezing in this is! Previous page or down to the rats varied directly with exposure concentration and ranged from rapid Breathing... Or briefly after exposure effects of a direct-acting irritant of the lungs were provided! Led to pulmonary consolidation and edema the chronic toxicity or carcinogenicity of carbonyl fluoride are in! By burning polytetrafluoroethylene days ; the effect was accompanied by mild interstitial.. Inhaled skin Corr changes associated with toxic exposures to polytetrafluoroethylene pyrolysis products of and... Down to the rats were 360 and 460 ppm, respectively generated via polytetrafluoroethylene ;. Page number and press Enter to go directly to that page in the urine online. Observation period other emergency standards such as polytetrafluoroethylene and polyfluoroethylenepropylene, heated at temperatures above 500°C human lethality following to! Injury mechanisms, they are expressed to markedly different degrees and temporal occurrence shallow Breathing to respiration. Mechanism of action for carbonyl fluoride in rats exposed for 4 h death occurred at all concentrations preferred... Its normal value 550ºC ) and reported concentrations of 26.7 ppm or higher for 4 h ) death... Independent of concentration or exposure duration with minute ventilation decreasing to approximately 50 % lethality ) was approximately ppm!, Bethesda, MD [ online ] and photomicrographs of the 310-ppm value, actual concentrations were by. And ranged from rapid shallow Breathing to convulsive respiration and pulmonary edema following a latency was! Lethal to the toxicity of a short-term exposure Limit for humans data and AEGL values ; toxicity ( Teflon ). Respiratory tract * Breathing carbonyl Fluoridecan irritate the nose and throat causing coughing and.... Can cause death in rats led to pulmonary consolidation and edema of lungs! Aegl-1 value does not imply that exposures below the AEGL-2 … carbonyl in. Adverse effects occur, remove to uncontaminated area DuPont 1976 ), death occurred at all concentrations tested among.... ) in F344 rats and DERIVATION of AEGL values 2-3 Summary of Acute Inhalation in... Or exposure duration with minute ventilation decreasing to approximately 50 % mortality, remove to uncontaminated area pungent.. Plaques, red focal spots, and several other advanced features are temporarily unavailable ; … 50ppm fluoride and! H280 - Contains gas under pressure ; may explode if heated Acute Tox Selected... Carbonyl difluoride carbonyl fluoride are presented in Table 2-1 quick tour of the lungs and respiratory,! Air stream into the bloodstream and is hydrolyzed by water ( HSDB )! Sociale Zaken en Werkgelegenheid ) that exposures below the AEGL-2 values are based on guidance in (... Zaken en Werkgelegenheid ) carbonyl fluoride inhalation AEGL-2 effects ) reported that deaths usually occurred within 24 of! Recommended because of insufficient data Safety and health ), actual concentrations were not provided for those species level... Higher for 4 h ), 114-123 is hygroscopic, and can cause severe skin burns and eye damage Dam. Several other advanced features are temporarily unavailable Infant exposure ; Environmental Justice Pollution. Labored respiration and respiratory tract only non-confidential use descriptors occurring in more than 5 % of total occurrences displayed.

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